Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments
نویسندگان
چکیده
منابع مشابه
Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments.
Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange-based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes, and generally can only be quantified through an asymmetry analysis of the water saturation spectrum (Z-spectrum) with respect to the water frequency, a proc...
متن کاملAnalytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
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A versatile method for assessing protein properties via magnetic resonance imaging (MRI) through chemical exchange saturation transfer (CEST) modality is described. The observed CEST signal changes allow monitoring of protein aggregation processes, protein folding/unfolding steps and interaction with lipid membranes.
متن کاملSimplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast.
Chemical exchange saturation transfer (CEST) imaging is sensitive to dilute labile proton and microenvironment properties such as pH and temperature, and provides vital information complementary to the conventional MRI methods. Whereas the Bloch equations coupled by exchange terms (i.e., Bloch-McConnell equations) have been utilized to quantify 2-pool CEST contrast, it is tedious to extend the ...
متن کاملAn Improved Empirical Solution for Describing Chemical Exchange Saturation Transfer (CEST) MRI
Introduction Both numerical simulation and analytical solution have been developed to describe CEST MRI phenomenon, which have aided our ability to quantify and optimize CEST imaging 1,2. In fact, a concise empirical solution has been proposed which decomposes CEST contrast as a product of the “ideal” contrast, saturation coefficient and spillover factor 3. However, the empirical solution is on...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2009
ISSN: 0740-3194
DOI: 10.1002/mrm.21873